Immune-modulators help the body to restore correct immune functions and, for example, control the damage caused by chronic inflammation, like that caused by cancer. As such, the effects of immune-modulators can also be highly relevant to several non-cancer diseases for which unregulated immune responses and persistent chronic inflammation is part of the problem. In particular these have been observed to drive allergic diseases, autoimmune diseases and inflammatory bowel disease as well as mood disorders.
IMM‑201 preferentially modulates the immune response towards control of over-exuberant immune responses (immune-regulation). It helps the body to control responses to harmless antigens present in its environment (e.g. pollen) and to control chronic inflammation that develop in conditions of stress which arise during infections (e.g. TB) or in life events (e.g. PTSD, sleep deprivation, anxiety).
IMM‑201 is a natural bacterium which would have been routinely consumed by our ancestors as part of their diet. Indeed, we have co-evolved with microbes present our environment including soil, water and our food for millions of years and have come to expect important clues in our immune system from them, providing a service essential to health. Only recently urban living conditions and modern living (e.g. inappropriate use of antibiotics, reduced animal interaction, processed food) have altered this balance. Immodulon is developing a strategy to “re-introduce” patients to beneficial bacteria to promote an optimal immune response to disease.